The research has numerous importance and you can limits

The research has numerous importance and you can limits

The target design smaller the potential for keep in mind and selection biases, and high rate out of maintenance quicker prejudice due to good loss to check out-up. Diet is examined multiple times through the follow-upwards, and that got into consideration changes in eating practices and you can reduced aspect error; however, some error was inescapable. Regardless of if strokes was basically thinking-advertised, research doctors, with no knowledge of the fresh new mind-advertised chance basis standing out-of participants, analyzed participants’ scientific records to ensure the fresh heart attack analysis and you will categorize the new stroke type of. But not, as twenty-four% of women having coronary attack in the NHS We and you may 32% regarding NHS II didn’t give consent to review their scientific information, we had been unable to categorize most of the shots since ischemic otherwise hemorrhagic; hence, the fresh variety of coronary arrest versions was in fact faster. Nonetheless, the large number of members plus the enough time duration of go after-upwards given enough capability to choose clinically relevant variations in threats out of total coronary attack and you can heart attack sizes. As well, the new updated meta-analyses considering service for our results towards the fat loss consumption out-of magnesium, potassium, and you may calcium supplements and danger of complete heart attack. A primary limitation of the most recent analysis is actually the shortcoming so you’re able to independent the fresh separate aftereffects of the three nutrients which have far confidence because of the large correlations between them. In addition to, just like the study population predominantly contained Caucasian girls ( 12), the outcome of most recent investigation is almost certainly not generalizable so you can boys or ethnically varied communities.

To summarize, is a result of these types of dos highest possible degree promote solid research in order to help a keen inverse relationship between combined consumption off magnesium, potassium, and you may calcium supplements of diet and coronary arrest exposure. Brand new separate part of each and every nutrient throughout the decrease in coronary arrest chance is tough to help you identify. At the same time, the effect of these nutrients with the risk of heart attack separate off dinner supplies is difficult in order to define. This study supporting counsel of Weight reduction Solutions to Prevent Blood circulation pressure, Optimum Macronutrient Consumption Trial to end Heart disease, and you will Mediterranean diet, hence promote higher dieting consumption ones nutrients.

The newest authors’ requirements was as follows-SNA: did analytical analyses and you can had written the newest manuscript; DS, WCW, and you will KMR: provided crucial viewpoints of your manuscript; and all experts: comprehend and you will acknowledged the last manuscript. None of the authors claimed a conflict interesting regarding the analysis.


Supported by the newest NIH (offers UM1CA176726, UM1CA186107, D43TW009106, HL34594, CA87969, and HL088521) and Bernard Lown Heart disease System (to SNA).


Information was obtained on potential confounding factors, including medical history, other aspects of dietary intake, and lifestyle behaviors that could be associated with intake of these minerals and risk of stroke. These variables were updated biennially and included cigarette smoking (never, past, or current), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks per week), menopausal status (premenopausal or postmenopausal), postmenopausal hormone therapy use (never, past, or current), parental history of early myocardial infarction (before age 60 y), multivitamin use (yes or no), thiazide use (yes or no), aspirin use at least 2 times/wk (yes or no), and history of hypertension, diabetes, or hypercholesterolemia (yes or no). Height and weight were self-reported at baseline, and weight was updated from follow-up questionnaire responses. BMI (in kg/m 2 ) was calculated as weight divided by height squared. BMI was divided into 3 categories (i.e., <25, 25 to <30, and ?30). Quintiles were calculated for total energy intake (kcal), and we used alcohol consumption categories of 0, 0 to <5, 5 to <10, 10 to <15, and ?15 g/d.

Age-standard properties out of 86,149 feamales in brand new NHS We for the 1994 and you can 94,715 women in this new NHS II for the 1995 by quintiles from magnesium, potassium, and calcium intakes step one

Pooled RRs (95% CIs) out-of full, ischemic, and you can hemorrhagic strokes by the quintiles away from overall and you will dietary potassium consumption inside the 86,149 ladies in the fresh NHS We and 94,715 feamales in the NHS II 1

Because of the apparently higher level of relationship ranging from such nutrients, i and additionally checked-out a mixed magnesium, potassium, and you will calcium eating plan get ( Table 5). To possess research of women on large with lower quintiles out-of mutual magnesium, potassium, and you will calcium supplements eating plan score, the latest pooled multivariate RR getting overall heart attack are 0.81 (95% CI: 0.72, 0.91; P-pattern = 0.003). Findings was in fact comparable for ischemic but not hemorrhagic heart attack.


The latest family ranging from consumption out of magnesium, potassium, and you may calcium and you will threat of coronary attack revealed in today’s studies is a lot like the new relation ranging from consumption of these nutrition and danger of IHD. In the prospective training, losing weight consumption regarding magnesium and you will potassium was inversely with the risk of IHD ( 46, 47), however, there’s zero relation that have calcium consumption and you will chance of IHD in women ( 48). And, consumption out of magnesium and calcium but not potassium have been of the all the way down chance of CVD death in a few ( twenty four, 46, 49) yet not every ( 50) training.

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